Endothelium derived relaxation factors reduce sulfur dioxide-induced aortic relaxation
نویسندگان
چکیده
منابع مشابه
Nitroarginine inhibits endothelium-derived relaxation.
Effects of NG-nitro-L-arginine (NO2Arg), a guanidinonitro arginine derivative, on acetylcholine-induced relaxation of rabbit thoracic aorta ring preparation were studied. Relaxation by acetylcholine was inhibited by NO2Arg dose-dependently and the maximum relaxation with 10(2) microM NO2Arg was reduced to 10.1 +/- 4.3% (n = 5). L-arginine (10(2) microM) did not affect the acetylcholine-induced ...
متن کاملSaffron Induced Relaxation in Isolated Rat Aorta via Endothelium Dependent and Independent Mechanisms
Crocus sativus L. (saffron) is a widely used food additive for its color and taste. The hypotensive effects of saffron have been shown in previous studies. The aim of this study was to evaluate the mechanism of vasodilatory effects induced by saffron on isolated rat aorta.To study the vasodilatory effects of saffron aqueous extract (0.5, 1 and 2 mg/mL), isolated rat thoracic aorta rings were co...
متن کاملSaffron Induced Relaxation in Isolated Rat Aorta via Endothelium Dependent and Independent Mechanisms
Crocus sativus L. (saffron) is a widely used food additive for its color and taste. The hypotensive effects of saffron have been shown in previous studies. The aim of this study was to evaluate the mechanism of vasodilatory effects induced by saffron on isolated rat aorta.To study the vasodilatory effects of saffron aqueous extract (0.5, 1 and 2 mg/mL), isolated rat thoracic aorta rings were co...
متن کاملSulfur dioxide: a physiologic endothelium-derived relaxing factor.
The gasotransmitter nitric oxide was classified as the first endothelium-derived relaxant factor, and opened a new era in cardiovascular research. Another small gas, sulfur dioxide (SO₂), can also be generated endogenously in mammals. Recent studies have shown that SO₂ may play important roles in the cardiovascular system. At low concentrations, the vasodilatory effect of SO₂ is endothelium-dep...
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To evaluate the acute effect of lovastatin on diabetic endothelial dysfunction, we examined this effect on the aortic rings of streptozotocin-diabetic rats. The endothelial function was assessed in aortic rings isolated from diabetic rats, 12 weeks after treatment with streptozotocin (45 mg/kg, i.p.). The concentration-response curve to acetylcholine (Ach) in the aortic rings precontracted with...
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ژورنال
عنوان ژورنال: Open Journal of Molecular and Integrative Physiology
سال: 2013
ISSN: 2162-2159,2162-2167
DOI: 10.4236/ojmip.2013.34023